The rise of the first trillion-dollar companies was one of a handful of big ideas entertained during a tech-focused panel that also featured Shana Fisher of High Line Venture Partners. Fisher was an early partner in video-sharing site Vine.
She said companies that can make it easier to make videos will do well.
"The technology limitations just dealing with getting something from your phone to the server is still a difficult hurdle," Fisher said. "The sky's the limit for video."
Breyer also predicted big things for digital currencies.
He said the leader in the field may not end up being bitcoin, which is the most prominent name now but has faced price volatility, theft and scandal over the past year. Other providers will emerge.
"I have zero doubt in the next five to seven years that we will see at least half a dozen multibillion dollar digital currency companies," he said.
—By CNBC's Jeff Cox
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